Diclofenac Acyl-beta-D-Glucuronide

Diclofenac acyl-beta-D-glucuronide is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor diclofenac (Cay-70680, Cay-22983). It is formed from diclofenac via UDP-glucuronosyltransferase (UGT) isoform UGT2B7. Diclofenac acyl-beta-D-glucuronide inhibits the proliferation of HT-29 colorectal adenocarcinoma cells (IC50 = 130 µM).Formal Name: beta-D-glucopyranuronic acid, 1-[2-[(2,6-dichlorophenyl)amino]benzeneacetate]. CAS Number: 64118-81-6. Synonyms: Diclofenac Glucuronide, Diclofenac-beta-D-glucuronide. Molecular Formula: C20H19Cl2NO8. Formula Weight: 472.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 277 nm. SMILES: ClC1=CC=CC(Cl)=C1NC2=C(CC(O[C@@H]3O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)=O)C=CC=C2. InChi Code: InChI=1S/C20H19Cl2NO8/c21-10-5-3-6-11(22)14(10)23-12-7-2-1-4-9(12)8-13(24)30-20-17(27)15(25)16(26)18(31-20)19(28)29/h1-7,15-18,20,23,25-27H,8H2,(H,28,29)/t15-,16-,17+,18-,20+/m0/s1. InChi Key: JXIKYYSIYCILNG-HBWRTXEVSA-N.