diABZI STING Agonist-1 (hydrochloride)

diABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of IFN-beta in human peripheral blood mononuclear cells (PBMCs, EC50 = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-beta, IL-6, TNF, and KC/GROalpha in wild-type, but not Sting-/-, mice. It inhibits the cytopathic effect of the common cold human coronavirus 229E (HCoV-229E) in infected MRC-5 cells (EC50 = 3 nM). diABZI STING agonist-1 also decreases the level of severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay. It decreases tumor volume and increases survival in a CT26 murine colorectal cancer model when administered at a dose of 3 mg/kg.Formal Name: 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide, trihydrochloride. CAS Number: 2138299-34-8. Synonyms: diABZI Stimulator of Interferon Genes Agonist 1, Diamidobenzimidazole Stimulator of Interferon Genes Agonist 1, Diamidobenzimidazole STING Agonist 1, Stimulator of Interferon Genes Agonist (Compound 3), STING Agonist (Compound 3). Molecular Formula: C42H51N13O7 . 3HCl. Formula Weight: 959.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 50 mg/ml. lambdamax: 267, 322 nm. SMILES: COC1=CC(C(N)=O)=CC(N/2)=C1N(C/C=C/CN3/C(NC4=C3C(OCCCN5CCOCC5)=CC(C(N)=O)=C4)=N/C(C6=CC(C)=NN6CC)=O)C2=N\C(C7=CC(C)=NN7CC)=O.Cl.Cl.Cl. InChi Code: InChI=1S/C42H51N13O7.3ClH/c1-6-54-31(19-25(3)49-54)39(58)47-41-45-29-21-27(37(43)56)23-33(60-5)35(29)52(41)12-8-9-13-53-36-30(46-42(53)48-40(59)32-20-26(4)50-55(32)7-2)22-28(38(44)57)24-34(36)62-16-10-11-51-14-17-61-18-15-51,,,/h8-9,19-24H,6-7,10-18H2,1-5H3,(H2,43,56)(H2,44,57)(H,45,47,58)(H,46,48,59),3*1H/b9-8+,,,. InChi Key: CKESNWHACHILIV-BILRHTGOSA-N.