Dexchlorpheniramine (maleate)

Dexchlorpheniramine is a histamine H1 receptor antagonist with a pA2 value of 9.36 in guinea pig ileal tissue in vitro. It inhibits the proliferation of previously sensitized, allergen-challenged peripheral blood mononuclear cells by 92% at a concentration of 4.8 µM. Dexchlorpheniramine reduces noradrenaline uptake in the rat vas deferens ex vivo in response to tyramine stimulation when used at a concentration of 10 µM. In vivo, dexchlorpheniramine increases the pain threshold of mice exposed to thermal and chemical stimulation tests when administered intraperitoneally at a dose of 30 mg/kg. Formulations containing dexchlorpheniramine have been used for the treatment of allergic reactions.Formal Name: gammaS-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine, 2Z-butenedioate. CAS Number: 2438-32-6. Synonyms: d-Chlorpheniramine (maleate), S-(+)-Chlorpheniramine (maleate), Fortamine. Molecular Formula: C16H19ClN2 . C4H4O4. Formula Weight: 390.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, DMF: Slightly Soluble, DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: ClC(C=C1)=CC=C1[C@H](CCN(C)C)C2=CC=CC=N2.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13,5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3,1-2H,(H,5,6)(H,7,8)/b,2-1-/t15-,/m0./s1. InChi Key: DBAKFASWICGISY-DASCVMRKSA-N.