Desethoxy Quetiapine (hydrochloride)

Desethoxy quetiapine is an active metabolite of the atypical antipsychotic quetiapine (Cay-14152). It is formed from quetiapine primarily by the cytochrome P450 (CYP) isoform CYP3A5 and binds to dopamine D2 receptors (IC50 = 1,330 nM). Desethoxy quetiapine (20 and 40 mg/kg) reduces climbing induced by the dopamine receptor agonist apomorphine in mice. It also improves apomorphine-induced swimming deficits in mice.Formal Name: 4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazineethanol, dihydrochloride. CAS Number: 329218-14-6. Synonyms: O-Desalkylquetiapine. Molecular Formula: C19H21N3OS . 2HCl. Formula Weight: 412.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: OCCN1CCN(CC1)C2=NC3=CC=CC=C3SC4=CC=CC=C42.Cl.Cl. InChi Code: InChI=1S/C19H21N3OS.2ClH/c23-14-13-21-9-11-22(12-10-21)19-15-5-1-3-7-17(15)24-18-8-4-2-6-16(18)20-19,,/h1-8,23H,9-14H2,2*1H. InChi Key: OXKMTOMGUPCOBA-UHFFFAOYSA-N.