Dequalinium (chloride)

Dequalinium is a quaternary ammonium cation with diverse biological activities. It has antifungal activity against C. albicans, C. glabrata, and C. krusei (MICs = 0.5-2, 64-256, and 128 µg/ml, respectively), antitrichomonal activity against T. vaginalis (MICs = 28.8-230.4 µg/ml), and antibacterial activity against a panel of aerobic and facultative anaerobic bacteria (MICs = 0.25-256 µg/ml). Dequalinium inhibits apamin binding to, and net potassium loss mediated by, SKCa channels in guinea pig hepatocytes stimulated by angiotensin II (Cay-17150). In vivo, dequalinium (1-10 mg/kg) inhibits primary and recurrent tumor growth in a W163 rat colon carcinoma isograft model.Formal Name: 1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-quinolinium, dichloride. CAS Number: 522-51-0. Synonyms: NSC 166454. Molecular Formula: C30H40N4 . 2Cl. Formula Weight: 527.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 210, 221, 242, 328, 341 nm. SMILES: CC1=[N+](CCCCCCCCCC[N+]2=C(C=CC=C3)C3=C(N)C=C2C)C4=CC=CC=C4C(N)=C1.[Cl-].[Cl-]. InChi Code: InChI=1S/C30H38N4.2ClH/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34,,/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3,2*1H. InChi Key: LTNZEXKYNRNOGT-UHFFFAOYSA-N.