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Description: Delpazolid (LCB01-0371), also known as LCB01-0371, is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic infections in mice was also evaluated. LCB01-0371 was more active than linezolid against these systemic infections. LCB01-0371 showed bacteriostatic activity against Staphylococcus aureus. Target: Antibiotic, Antibacterial. Smiles: CN1CCN(C=N1)c1ccc(cc1F)N1C[C@H](CO)OC1=O. References: Jeong JW, et al.In vitro and in vivo activities of LCB01-0371, a new oxazolidinone.Antimicrob Agents Chemother. 2010 Dec,54(12):5359-62. Jeong JW1,
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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