Dehydro Nifedipine
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Larger quantity required? Request bulk
Description: Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human... more
Product information "Dehydro Nifedipine"
Description: Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 µM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. Target: Others. Smiles: COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c1ccccc1[N+]([O-])=O. References: Shimada T, et al. Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proc Natl Acad Sci U S A. 1989,86(2):462-465.
| Keywords: | BAY-b 4759 |
| Supplier: | TargetMol |
| Supplier-Nr: | T36665 |
Properties
| Application: | Active nifedipine metabolite |
| MW: | 344.32 D |
| Formula: | C17H16N2O6 |
Database Information
| CAS : | 67035-22-7| Matching products |
| KEGG ID : | K17690 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H318 |
| P Phrases: | P280, P305+351+338, P310 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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