Decamethonium (bromide)

Decamethonium is a depolarizing neuromuscular blocking agent. It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs). Decamethonium activates alpha1beta1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 µM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse alpha7-, alpha3beta2-, alpha3beta4-, and alpha4beta2-containing receptors with IC50 values of 7.4, 405, 28, and 59 µM, respectively. Decamethonoium is a competitive antagonist of alpha4beta2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 µM for the human receptor). It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 µg/kg for cats under chloralose and ether anesthesia, respectively. Formulations containing decamethonium have been used to induce paralysis during anesthesia.Formal Name: N1,N1,N1,N10,N10,N10-hexamethyl-1,10-decanediaminium, dibromide. CAS Number: 541-22-0. Molecular Formula: C16H38N2 . 2Br. Formula Weight: 418.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 16 mg/ml, Ethanol: 33 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: C[N+](CCCCCCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]. InChi Code: InChI=1S/C16H38N2.2BrH/c1-17(2,3)15-13-11-9-7-8-10-12-14-16-18(4,5)6,,/h7-16H2,1-6H3,2*1H/q+2,,/p-2. InChi Key: HLXQFVXURMXRPU-UHFFFAOYSA-L.