Dbet57

Description: dBET57 is heterobifunctional degrader of BRD4 based on the PROTAC technology, exhibits significant degradation of BRD4BD1 with a DC50/5h of 500 nM ,and inactive on BRD4BD2. Target: PROTACs, Epigenetic Reader Domain. Smiles: CC=1C2=C(N3C([C@H](CC(NCCNC4=C5C(C(=O)N(C5=O)C6C(=O)NC(=O)CC6)=CC=C4)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C. References: Nowak RP, et al. Plasticity in binding confers selectivity in ligand-induced protein degradation. Nat Chem Biol. 2018 Jul,14(7):706-714.