Daunorubicin (hydrochloride)

Daunorubicin is an antitumor antibiotic. At 0.2-1µM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia (AML) cells. However, immature AML cells (CD 34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations. In mature AML cells, daunorubicin has been shown to trigger a reactive oxygen species-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK cascade leading to enhanced DNA binding activity of the transcription factor AP-1.Formal Name: 8S-acetyl-10S-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione, monohydrochloride. CAS Number: 23541-50-6. Synonyms: NDC 0082-4155, Ondena, RP 13057. Molecular Formula: C27H29NO10 . HCl. Formula Weight: 564.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.5 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 234, 251, 288, 480 nm. SMILES: COC1=C(C(C(C(O)=C([C@@H](O[C@@]2([H])C[C@H](N)[C@H](O)[C@H](C)O2)C[C@@](C(C)=O)(O)C3)C3=C4O)=C4C5=O)=O)C5=CC=C1.Cl. InChi Code: InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33,/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3,1H/t10-,14-,16-,17-,22+,27-,/m0./s1. InChi Key: GUGHGUXZJWAIAS-QQYBVWGSSA-N.