Daunorubicin-13C-d3

Daunorubicin-13C-d3 is intended for use as an internal standard for the quantification of daunorubicin (Cay-14159) by GC- or LC-MS. Daunorubicin is an antitumor antibiotic. At 0.2-1 µM, daunorubicin induces apoptosis in mature monocytic U937 and myelocytic HL-60 acute myeloid leukemia (AML) cells. However, immature AML cells (CD34+-KG1a, -KG1, or -HEL cells) appear resistant to apoptosis at similar concentrations. In mature AML cells, daunorubicin has been shown to trigger a reactive oxygen species-dependent sphingomyelin-ceramide pathway that activates the MEKK1-SEK1-JNK cascade leading to enhanced DNA binding activity of the transcription factor AP-1.Formal Name: 8S-acetyl-10S-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-(methoxy-13C-d3)-5,12-naphthacenedione. Molecular Formula: C26[13C]H26D3NO10. Formula Weight: 531.5. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble. SMILES: O=C1C2=C(C(O)=C([C@@H](O[C@@]3([H])C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(C)=O)(O)C4)C4=C2O)C(C5=C(O[13C]([2H])([2H])[2H])C=CC=C51)=O. InChi Code: InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1/i3+1D3. InChi Key: STQGQHZAVUOBTE-GRHMMMPSSA-N.