Dasatinib monohydrate
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic... more
Product information "Dasatinib monohydrate"
Description: Dasatinib monohydrate (BMS-354825 Monohydrate) is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib monohydrate binds to and inhibits the growth-promoting activities of these kinases. Apparently, because of its less stringent binding affinity for the BCR-ABL kinase, Dasatinib monohydrate has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. Target: Apoptosis, Bcr-Abl, Autophagy, Ephrin Receptor, Src, c-Kit. Smiles: n1cc(sc1Nc1nc(nc(N2CCN(CC2)CCO)c1)C)C(=O)Nc1c(cccc1C)Cl.O. References: O'Hare T, et al. Cancer Res. 2005, 65(11), 4500-4505.
| Keywords: | BMS-354825 Monohydrate |
| Supplier: | TargetMol |
| Supplier-Nr: | T1448L |
Properties
| Application: | Targets abelson tyrosine-protein kinase 1 [EC:2.7.10.2] (ABL1) |
| MW: | 506.03 D |
| Formula: | C22H28ClN7O3S |
Database Information
| CAS : | 863127-77-9| Matching products |
| KEGG ID : | K05089 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H300, H360, H361, H372, H410 |
| P Phrases: | P201, P202, P260, P264, P270, P273, P280, P314, P321, P330, P391, P301+P310, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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