Darodipine

Darodipine is a calcium channel inhibitor. It selectively inhibits calcium-induced contractions of isolated rabbit aorta (pD2 = 8.8) over norepinephrine-, serotonin-, or angiotensin II-induced contractions at 10 µM. In vivo, continuous infusion of darodipine (2 µg/kg per minute) increases cerebral tissue oxygenation in a cat model of focal ischemia induced by cerebral artery occlusion (CAO). Darodipine (5 mg/kg) reduces mean arterial blood pressure and increases arterial luminal area in spontaneously hypertensive rats (SHRs).Formal Name: 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester. CAS Number: 72803-02-2. Synonyms: PY 108-068. Molecular Formula: C19H21N3O5. Formula Weight: 371.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: CC1=C(C(OCC)=O)C(C(C(OCC)=O)=C(N1)C)C2=CC=CC3=NON=C32. InChi Code: InChI=1S/C19H21N3O5/c1-5-25-18(23)14-10(3)20-11(4)15(19(24)26-6-2)16(14)12-8-7-9-13-17(12)22-27-21-13/h7-9,16,20H,5-6H2,1-4H3. InChi Key: QERUYFVNIOLCHV-UHFFFAOYSA-N.