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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay29451-1 | 1 mg | - |
6 - 10 business days* |
286.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Dantrolene-d4 is intended for use as an internal standard for the quantification of dantrolene... more
Product information "Dantrolene-d4"
Dantrolene-d4 is intended for use as an internal standard for the quantification of dantrolene (Cay-14326) by GC- or LC-MS. Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 µM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 µM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 µM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 µg/ml) and MHS pigs (ED50 = 0.85 mg/kg).. Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.Formal Name: 1-[[[5-(4-nitrophenyl-2,3,5,6-d4)-2-furanyl]methylene]amino]-2,4-imidazolidinedione. CAS Number: 2749234-17-9. Molecular Formula: C14H6D4N4O5. Formula Weight: 318.3. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(NC(C1)=O)N1N=CC2=CC=C(C3=C([2H])C([2H])=C([N+]([O-])=O)C([2H])=C3[2H])O2. InChi Code: InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)/i1D,2D,3D,4D. InChi Key: OZOMQRBLCMDCEG-RHQRLBAQSA-N.
Keywords: | 1-[[[5-(4-nitrophenyl)-furanyl]methylene]amino]-2,4-imidazolidinedione |
Supplier: | Cayman Chemical |
Supplier-Nr: | 29451 |
Properties
Application: | GC-MS, LC-MS, internal standard, Ca2+ release inhibitor |
MW: | 318.3 D |
Formula: | C14H6D4N4O5 |
Purity: | >99% deuterated forms (d1-d4) |
Format: | Solid |
Database Information
CAS : | 2749234-17-9| Matching products |
KEGG ID : | K04961 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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