Dantrolene-d4

Dantrolene-d4
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay29451-1 1 mg -

6 - 10 business days*

286.00€
 
Dantrolene-d4 is intended for use as an internal standard for the quantification of dantrolene... more
Product information "Dantrolene-d4"
Dantrolene-d4 is intended for use as an internal standard for the quantification of dantrolene (Cay-14326) by GC- or LC-MS. Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 µM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 µM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 µM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 µg/ml) and MHS pigs (ED50 = 0.85 mg/kg).. Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.Formal Name: 1-[[[5-(4-nitrophenyl-2,3,5,6-d4)-2-furanyl]methylene]amino]-2,4-imidazolidinedione. CAS Number: 2749234-17-9. Molecular Formula: C14H6D4N4O5. Formula Weight: 318.3. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=C(NC(C1)=O)N1N=CC2=CC=C(C3=C([2H])C([2H])=C([N+]([O-])=O)C([2H])=C3[2H])O2. InChi Code: InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)/i1D,2D,3D,4D. InChi Key: OZOMQRBLCMDCEG-RHQRLBAQSA-N.
Keywords: 1-[[[5-(4-nitrophenyl)-furanyl]methylene]amino]-2,4-imidazolidinedione
Supplier: Cayman Chemical
Supplier-Nr: 29451

Properties

Application: GC-MS, LC-MS, internal standard, Ca2+ release inhibitor
MW: 318.3 D
Formula: C14H6D4N4O5
Purity: >99% deuterated forms (d1-d4)
Format: Solid

Database Information

CAS : 2749234-17-9| Matching products
KEGG ID : K04961 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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