Dabrafenib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E... more
Product information "Dabrafenib"
Description: Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma. Target: Raf. Smiles: CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F. References: King AJ, et al. Dabrafenib, preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions. PLoS One. 2013 Jul 3,8(7):e67583.
| Keywords: | GSK2118436A, GSK2118436 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1903 |
Properties
| Application: | Targets B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] (BRAF) |
| MW: | 519.56 D |
| Formula: | C23H20F3N5O2S2 |
Database Information
| CAS : | 1195765-45-7| Matching products |
| KEGG ID : | K04365 | Matching products |
| Protein Atlas Nr. : | Ser/Thr Phosphorylation |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H361, H373, H400, H411 |
| P Phrases: | P201, P202, P260, P273, P280, P314, P391, P308+P313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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