D-Glucuronic Acid

D-Glucuronic acid is a metabolite of glucose. It is formed from glucose in a multi-step process in which uridine diphosphate glucose (UDP-alpha-D-glucose, Cay-15602) is dehydrogenated to uridine diphosphate glucuronic acid (uridine-5'-diphosphoglucuronic acid, Cay-20674), from which D-glucuronic acid can be transferred to a receptor to form glucuronides, further metabolized to ascorbic acid or xylulose, or excreted. D-Glucuronic acid is a component of proteoglycans, including heparan sulfate and chondroitin sulfate. Levels of D-glucuronic acid are increased in fibroblasts isolated from patients with infantile free sialic acid storage disease (ISSD) or Salla disease, lysosomal storage disorders characterized by truncal ataxia and psychomotor retardation and heptatosplenomegaly and impaired growth, respectively.CAS Number: 6556-12-3. Synonyms: D-(+)-Glucuronic Acid. Molecular Formula: C6H10O7. Formula Weight: 194.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: slightly soluble, PBS (pH 7.2): 10 mg/ml. SMILES: O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O. InChi Code: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/t2-,3+,4-,5-/m0/s1. InChi Key: IAJILQKETJEXLJ-QTBDOELSSA-N.