Cytochalasin E

The cytochalasins are cell-permeable fungal metabolites which inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin E is an epoxide-containing analog of cytochalasin B (Cay-11328) which potently and selectively inhibits the growth of endothelial cells (IC50 1 protease activity.Formal Name: (1E,4S,6R,7E,11aS,14S,14aS,15S,15aR,16aS,16bS)-3,13,14,14a,15,15a,16a,16b-octahydro-6-hydroxy-4,6,15,15a-tetramethyl-14-(phenylmethyl)-[1,3]dioxacyclotridecino[4,5-d]oxireno[f]isoindole-5,10,12(4H,6H)-trione. CAS Number: 36011-19-5. Synonyms: NSC 175151. Molecular Formula: C28H33NO7. Formula Weight: 495.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 11 mg/ml, DMF:PBS (pH7.2) (1:30): 0.03 mg/ml, DMSO: 10 mg/ml, Ethanol: 2 mg/ml. SMILES: O=C(OC12[C@@]([C@H]3[C@](C)(O3)[C@@H](C)[C@@]1([H])[C@H](CC4=CC=CC=C4)NC2=O)([H])/C=C/C[C@]5([H])C)O/C=C/[C@](O)(C)C5=O. InChi Code: InChI=1S/C28H33NO7/c1-16-9-8-12-19-23-27(4,35-23)17(2)21-20(15-18-10-6-5-7-11-18)29-24(31)28(19,21)36-25(32)34-14-13-26(3,33)22(16)30/h5-8,10-14,16-17,19-21,23,33H,9,15H2,1-4H3,(H,29,31)/b12-8+,14-13+/t16-,17-,19-,20-,21-,23-,26+,27+,28?/m0/s1. InChi Key: LAJXCUNOQSHRJO-KGDUIROVSA-N. Origin: Fungus/Aspergillus clavatus.