Cytarabine-13C3

Cytarabine-13C3 (ara-C-13C3) is intended for use as an internal standard for the quantification of ara-C (Cay-16069) by GC- or LC-MS. Ara-C is a nucleoside analog and prodrug form of the DNA polymerase inhibitor ara-CTP. It is triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase, deoxycytidylate kinase, and nucleoside diphosphate kinase. Ara-C inhibits proliferation of HL-60, ML-1, Raji, and Jurkat human leukemia cell lines with IC50 values of 37, 17, 16, and 72 nM, respectively. It induces cell cycle arrest at the G0/G1 phase in HL-60 cells when used at concentrations of 2.5 and 15 µM. Ara-C (75 mg/kg per day, i.p.) reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model. It also increases survival and reduces brain herpesvirus titers in infected rats when administered subcutaneously at doses of 80 and 320 mg/kg. Formulations containing ara-C have been used in the treatment of acute myeloid leukemia.Formal Name: 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone-4,5,6-13C3. Synonyms: Ara-C-13C3, 1-beta-D-Arabinofuranosylcytosine-13C3. Molecular Formula: C6[13C3]H13N3O5. Formula Weight: 246.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: warmed, Water: slightly soluble. SMILES: O[C@@H]1[C@H](N2C(N=[13C](N)[13CH]=[13CH]2)=O)O[C@H](CO)[C@H]1O. InChi Code: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1/i1+1,2+1,5+1. InChi Key: UHDGCWIWMRVCDJ-BOZZUQJYSA-N.