CyPPA

CyPPA is a positive modulator of the small-conductance calcium-activated potassium channels KCa2.2/SK2 and KCa2.3/SK3 (EC50s = 14 and 5.6 µM, respectively). It is inactive on both KCa2.1/SK1 and the intermediate conductance calcium-activated potassium channel, KCa3.1/SK4. At KCa2.3/SK3, CyPPA increases the apparent calcium-sensitivity of channel activation, changing the EC50 value of calcium activation from 429 to 59 nM. CyPPA is used to evaluate the roles of KCa2.2/SK2 and KCa2.3/SK3 in such diverse processes as memory encoding, uterine muscle contraction, and dopamine signaling.Formal Name: N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine. CAS Number: 73029-73-9. Molecular Formula: C16H23N5. Formula Weight: 285.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 100 mM. lambdamax: 245 nm. SMILES: CC1=NC(N2N=C(C)C=C2C)=NC(NC3CCCCC3)=C1. InChi Code: InChI=1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19). InChi Key: USEMRPYUFJNFQN-UHFFFAOYSA-N.