Curvularin

Curvularin is a natural fungal macrolactone that has cytotoxic activity against select cancer cell lines. It inhibits cytokine-induced expression of induced nitric oxide synthase (iNOS, IC50 = 9.5 µM) in vitro and reduces proinflammatory gene expression in a mouse model of rheumatoid arthritis. Curvularin also blocks TGF-beta signaling in HepG2 and MDA-MB-231 cells.Formal Name: (4S)-4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione. CAS Number: 10140-70-2. Synonyms: (-)-Curvularin, (S)-Curvularin, NSC 166071. Molecular Formula: C16H20O5. Formula Weight: 292.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2)(1:9): 0.1 mg/ml, Ethanol: 10 mg/ml. lambdamax: 222, 272, 303 nm. SMILES: O=C(CCCCC[C@H](C)O1)C(C(O)=CC(O)=C2)=C2CC1=O. InChi Code: InChI=1S/C16H20O5/c1-10-5-3-2-4-6-13(18)16-11(8-15(20)21-10)7-12(17)9-14(16)19/h7,9-10,17,19H,2-6,8H2,1H3/t10-/m0/s1. InChi Key: VDUIGYAPSXCJFC-JTQLQIEISA-N.