Curcumin (high purity)

Curcumin (high purity)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
AG-CN2-0059-M010 10 mg -

3 - 9 business days*

39.00€
AG-CN2-0059-M050 50 mg -

3 - 9 business days*

94.00€
AG-CN2-0059-M250 250 mg -

3 - 9 business days*

319.00€
 
Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle... more
Product information "Curcumin (high purity)"
Anti-cancer compound. Interferes with multiple cell signaling pathways, including cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of anti-apoptotic gene products), proliferation (HER-2, EGFR and AP-1), survival (PI3K/AKT pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-4) and inflammation (NF-kappaB, TNF, IL-6, IL-1, COX-2 and 5-LOX). Anti-angiogenic. Anti-metastatic. Anti-invasive. Chemopreventive. Hedgehog signaling (Hh) modulator. Downregulates Shh and Gli1. Antioxidant. Anti-inflammatory. Potent inhibitor of NF-kappaB, cyclooxygenase-2 (COX-2), lipooxygenase (LOX), and inducible nitric oxide synthase (iNOS, NOSII). Downregulates the expression of various proinflammatory cytokines including TNF, IL-1, IL-2, IL-6, IL-8, IL-12 and chemokines. Potent immunomodulator. Modulates several key transcription factors. Down-regulate transcription factors NF-kappaB, AP-1 and Egr-1. Down-regulates the expression of COX-2, LOX, NOS, MMP-9, uPA, TNF, chemokines, cell surface adhesion molecules and cyclin D1. Down-regulate growth factor receptors (such as EGFR and HER2) and inhibits the activity of c-Jun N-terminal kinase, protein tyrosine kinases and protein serine/threonine kinases. Neuroprotective. Anti-amyloid activity. Cardioprotective. p300/CBP-HAT inhibitor. Regulates lipid metabolism and downregulates obesity. Activates peroxisome proliferator-activated receptor-gamma (PPARgamma) and Nrf2 cell-signaling pathways. Antiviral, antibacterial, antifungal. Epigenetic agent. Interacts with histone deacetylases (HDACs), histone acetyltransferases (HATs), DNA methyltransferase I and microRNAs.
Keywords: BRN 2306965, CCRIS 3257, NSC 32982, NSC 687842, CI 75300
Supplier: AdipoGen Life Sciences
Supplier-Nr: AG-CN2-0059

Properties

Application: Metabolic studies
Host: Synthetic
MW: 368,4 D
Formula: C21H20O6
Purity: >98%
Format: Solid

Database Information

CAS : 458-37-7| Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: +20°C)
GHS Hazard Pictograms:
H Phrases: H302, H315, H319, H335
P Phrases: P261, P264, P271, P280
Caution
Our products are for laboratory research use only: Not for administration to humans!
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