Cucurbitacin IIa

Cucurbitacin IIa is a triterpenoid that has been found in H. amabilis and has diverse biological activities. It decreases the proliferation of (IC50 = 370 nM), and induces cell cycle arrest at the G2/M phase and apoptosis in, HT-29 colorectal adenocarcinoma cells when used at a concentration of 1 µM. Cucurbitacin IIa (2.5 µM) induces cell cycle arrest at the G0/G1 phase in LPS-stimulated, but not unstimulated, RAW 264.7 macrophages. In vivo, cucurbitacin IIa (5 mg/kg) decreases immobility time in the forced swim test and the tail suspension test in a mouse model of intermittent unpredictable stress.Formal Name: (2beta,3alpha,9beta,10alpha,16alpha)-25-(acetyloxy)-2,3,16,20-tetrahydroxy-9-methyl-19-norlanost-5-ene-11,22-dione. CAS Number: 58546-34-2. Synonyms: Dihydrocucurbitacin Q1, Hemslecin A. Molecular Formula: C32H50O8. Formula Weight: 562.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: C[C@]12[C@@]([C@]([C@@](C(CCC(C)(C)OC(C)=O)=O)(C)O)([H])[C@@H](C1)O)(CC([C@@]3([C@@]2([H])CC=C4[C@@]3([H])C[C@@H]([C@H](C4(C)C)O)O)C)=O)C. InChi Code: InChI=1S/C32H50O8/c1-17(33)40-27(2,3)13-12-23(36)32(9,39)25-21(35)15-29(6)22-11-10-18-19(14-20(34)26(38)28(18,4)5)31(22,8)24(37)16-30(25,29)7/h10,19-22,25-26,34-35,38-39H,11-16H2,1-9H3/t19-,20+,21-,22+,25+,26-,29+,30-,31+,32+/m1/s1. InChi Key: LKYNAQSYQLFTCM-GYXNDICUSA-N. Origin: Plant/Hemsleya amabilis Diels.