CU-CPT17e

CU-CPT17e is an agonist of toll-like receptor 3 (TLR3), TLR8, and TLR9. It selectively induces NF-kappaB activation in HEK293 cells expressing recombinant human TLR3, TLR8, or TLR9 (EC50s = 4.8, 13.45, and 5.66 µM, respectively) over HEK293 cells expressing recombinant human TLR2, TLR4, TLR5, or TLR7 (EC50s = >100 µM for all). CU-CPT17e (5-40 µM) induces TNF-alpha, IL-6, and IL-8 production in THP-1 cells. It also inhibits the growth of HeLa cells (IC50 = 2.71 µM).Formal Name: 2',3',5',6'-tetrahydro-6,7-bis[(4-nitrophenyl)methoxy]-spiro[2H-1-benzopyran-2,4'-[4H]pyran]. CAS Number: 2109805-75-4. Molecular Formula: C27H24N2O8. Formula Weight: 504.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, Ethanol: Slightly soluble. SMILES: O=[N+](C1=CC=C(COC2=CC(C=CC3(CCOCC3)O4)=C4C=C2OCC5=CC=C([N+]([O-])=O)C=C5)C=C1)[O-]. InChi Code: InChI=1S/C27H24N2O8/c30-28(31)22-5-1-19(2-6-22)17-35-25-15-21-9-10-27(11-13-34-14-12-27)37-24(21)16-26(25)36-18-20-3-7-23(8-4-20)29(32)33/h1-10,15-16H,11-14,17-18H2. InChi Key: LHTNFHWDTHQECR-UHFFFAOYSA-N.