CU-32

Description: CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS, IC50= 0.45 µM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 µM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-beta in THP-1 cells when used at concentrations of 10, 30, and 100 µM. Target: Others. Smiles: N(C=1N=C(C(OC)=O)N=C(N)N1)C2=CC=C(I)C=C2. References: Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP synthase inhibitorsJ. Org. Chem.85(3)1579-1600(2020)