Crizotinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinase... more
Product information "Crizotinib"
Description: Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinase inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptors. Target: ROS Kinase, c-Met/HGFR, Autophagy, ROS, ALK. Smiles: O([C@H](C)C1=C(Cl)C(F)=CC=C1Cl)C2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N. References: Zou HY, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007 May 1,67(9):4408-17.
| Keywords: | PF-02341066 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1661 |
Properties
| Application: | Targets anaplastic lymphoma kinase [EC:2.7.10.1] (ALK, CD246) |
| MW: | 450.34 D |
| Formula: | C21H22Cl2FN5O |
Database Information
| CAS : | 877399-52-5| Matching products |
| KEGG ID : | K05088 | Matching products |
| Protein Atlas Nr. : | Tyrosine Phosphorylation |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H317, H319, H341, H400 |
| P Phrases: | P201, P202, P261, P264, P272, P273, P280, P321, P391, P302+P352, P305+P351+P338, P308+P313, P333+P313, P337+P313, P362+P364, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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