CPTH6 (hydrobromide)

CPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP. It blocks the acetylation of H3/H4 histones and alpha-tubulin in several leukemia cell lines. CPTH6 reduces cell viability, arresting cell cycling in the G0/G1 phase and inducing apoptosis. It impairs autophagy in a variety of tumor cell lines, at least in part by altering ATG7-mediated elongation of autophagosomal membranes.Formal Name: 3-methyl-cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone, monohydrobromide. CAS Number: 2321332-57-2. Molecular Formula: C15H16ClN3S . HBr. Formula Weight: 386.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 250, 278 nm. SMILES: ClC(C=C1)=CC=C1C2=CSC(N/N=C3CCC(C)C\3)=N2.Br. InChi Code: InChI=1S/C15H16ClN3S.BrH/c1-10-2-7-13(8-10)18-19-15-17-14(9-20-15)11-3-5-12(16)6-4-11,/h3-6,9-10H,2,7-8H2,1H3,(H,17,19),1H/b18-13+,. InChi Key: FTEQRZOKSCOLKS-PUBYZPQMSA-N.