CP 671,305

CP 671,305 is a potent inhibitor of phosphodiesterase 4D (PDE4D, IC50 = 3 nM). It is selective for PDE4D over PDE4A, -B, and -C (IC50s = 310, 287, and 3,858 nM, respectively), as well as over PDE1-3 and 5 (IC50s = >5,000 nM for all). CP 671,305 inhibits release of leukotriene E4 (LTE4, Cay-20410) from eosinophils (IC50 = 52 nM) and LTB4 (Cay-20110) from neutrophils (IC50 = 106 nM). In vivo, CP 671,305 inhibits antigen-induced pulmonary eosinophil influx in cynomolgus monkeys in a dose-dependent manner.Formal Name: (2R)-2-[4-[[[[2-(1,3-benzodioxol-5-yloxy)-3-pyridinyl]carbonyl]amino]methyl]-3-fluorophenoxy]-propanoic acid. CAS Number: 445295-04-5. Molecular Formula: C23H19FN2O7. Formula Weight: 454.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO: 25 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 279 nm. SMILES: OC([C@@H](C)OC1=CC(F)=C(CNC(C2=CC=CN=C2OC3=CC=C(OCO4)C4=C3)=O)C=C1)=O. InChi Code: InChI=1S/C23H19FN2O7/c1-13(23(28)29)32-15-5-4-14(18(24)9-15)11-26-21(27)17-3-2-8-25-22(17)33-16-6-7-19-20(10-16)31-12-30-19/h2-10,13H,11-12H2,1H3,(H,26,27)(H,28,29)/t13-/m1/s1. InChi Key: CNIGFESSDPOCKS-CYBMUJFWSA-N.