CP 466,722

CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 µM. It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 µM, respectively).Formal Name: 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine. CAS Number: 1080622-86-1. Molecular Formula: C17H15N7O2. Formula Weight: 349.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 2 mg/ml. lambdamax: 243, 364 nm. SMILES: COC(C(OC)=C1)=CC2=C1C(N3N=C(C4=CC=CC=N4)N=C3N)=NC=N2. InChi Code: InChI=1S/C17H15N7O2/c1-25-13-7-10-12(8-14(13)26-2)20-9-21-16(10)24-17(18)22-15(23-24)11-5-3-4-6-19-11/h3-9H,1-2H3,(H2,18,22,23). InChi Key: ILBRKJBKDGCSCB-UHFFFAOYSA-N.