CP-392,110 (maleate)

CP-392,110 is an AMPA receptor antagonist. It inhibits AMPA receptor-mediated calcium uptake in rat cerebellar neurons (IC50 = 74 nM). CP-392,110 inhibits seizures induced by pentylenetetrazol (Cay-18682) or AMPA (Cay-14571) in mice with ID50 values of 3.8 and 3.6 mg/kg, respectively.Formal Name: 3-(2-chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone, (2Z)-2-butenedioate. CAS Number: 199656-46-7. Molecular Formula: C26H24ClFN4O . C4H4O4. Formula Weight: 579.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 213, 334 nm. SMILES: FC1=CC=C2C(C(N(C3=C(Cl)C=CC=C3)C(/C=C/C4=CC=CC(CN(CC)CC)=N4)=N2)=O)=C1.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C26H24ClFN4O.C4H4O4/c1-3-31(4-2)17-20-9-7-8-19(29-20)13-15-25-30-23-14-12-18(28)16-21(23)26(33)32(25)24-11-6-5-10-22(24)27,5-3(6)1-2-4(7)8/h5-16H,3-4,17H2,1-2H3,1-2H,(H,5,6)(H,7,8)/b15-13+,2-1-. InChi Key: WLLUWLRVXIHECY-KSUUAYPFSA-N.