CP 339,818 (hydrochloride)

CP 339,818 is an inhibitor of voltage-gated potassium channel Kv1.3 and Kv1.4 (IC50s = 0.23 and 0.3 µM, respectively). It is selective for these channels over Kv1.1, Kv1.2, Kv1.5, and Kv1.6 channels (IC50s = 62, 14, 19, and 20 µM, respectively), as well as Kv3.1, Kv3.2, Kv3.4, and Kv4.2 channels (IC50s = 17, 10, 36, and >10 µM, respectively). CP 339,818 inhibits thymidine incorporation, a marker of T cell activation, induced by an anti-CD3 antibody or a combination of ionomycin (Cay-10004974, Cay-11932) and phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in isolated human peripheral blood T cells (IC50s = 4.7 and 5.2 µM, respectively).Formal Name: N-[1-(phenylmethyl)-4(1H)-quinolinylidene]-1-pentanamine, monohydrochloride. CAS Number: 478341-55-8. Molecular Formula: C21H24N2 . HCl. Formula Weight: 340.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Ethanol: Slightly soluble: 0.1-1 mg/ml. SMILES: CCCCCN=C1C=CN(CC2=CC=CC=C2)C3=C1C=CC=C3.Cl. InChi Code: InChI=1S/C21H24N2.ClH/c1-2-3-9-15-22-20-14-16-23(17-18-10-5-4-6-11-18)21-13-8-7-12-19(20)21,/h4-8,10-14,16H,2-3,9,15,17H2,1H3,1H. InChi Key: JIRISCAPZWLWCG-UHFFFAOYSA-N.