Cot inhibitor-2

Item number	Size	Manual	Delivery time	Price
TGM-T10866-1mg	1 mg	-	7 - 10 business days*	91.00€
TGM-T10866-2mg	2 mg	-	7 - 10 business days*	134.00€
TGM-T10866-5mg	5 mg	-	7 - 10 business days*	222.00€
TGM-T10866-1mL	1 ml	-	7 - 10 business days*	262.00€
TGM-T10866-10mg	10 mg	-	7 - 10 business days*	359.00€
TGM-T10866-25mg	25 mg	-	7 - 10 business days*	742.00€
TGM-T10866-50mg	50 mg	-	7 - 10 business days*	1,304.00€
TGM-T10866-100mg	100 mg	-	7 - 10 business days*	2,149.00€
TGM-T10866-500mg	500 mg	-	7 - 10 business days*	4,300.00€

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Description: Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency,... more

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Product information "Cot inhibitor-2"

Description: Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-alpha production in human whole blood with an IC50 of 0.3 µM. Target: TNF, MAPK. Smiles: CCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1. References: Wu J, et al. Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood. Bioorg Med Chem Lett. 2009 , 19(13):3485-3488.

Supplier:	TargetMol
Supplier-Nr:	T10866

Properties

Application:	COT (MAP3K8) inhibitor
MW:	539.43 D
Formula:	C26H25Cl2FN8

Database Information

CAS :	915363-56-3\| Matching products
KEGG ID :	K04415 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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