Corosolic acid

White to off-white powder. Soluble in DMSO (10mg/ml) or methanol (1 mg/ml). Chemical. CAS: 4547-24-4. Formula: C30H48O4. MW: 472.70. Corosolic acid is a triterpene phytochemical found in medicinal herbal extracts. It possesses antiatherosclerotic, antihyperlipidemic/antidiabetic, antioxidant, anti-inflammatory, antifungal, antiviral and antitumor activities. It is an apoptotic agent that induces caspase-8, -9 and -3 activation and shows antiproliferative effects against cancer cell lines. It stimulates glucose uptake via enhancing insulin receptor phosphorylation and ameliorates obesity in vivo. It has been shown to exhibit antiangiogenic and antilymphangiogenic effects in vitro and in vivo. Has also been shown to inhibit mitochondrial fission and NOX2 expression preventing NLRP3 inflammasome activation. It inhibits adipose tissue inflammation and ameliorate insulin resistance via AMPK activation and is an alpha-glucosidase inhibitor.