Conglobatin B

Conglobatin B is a bacterial metabolite that has been found in Streptomyces MST-91080 and has anticancer activity. It is cytotoxic to NS-1 mouse myeloma cells (IC50 = 0.084 µg/ml) but not NFF human fibroblasts (IC50 = >100 µg/ml).Formal Name: 3E,5R,7S,11E,15S-pentamethyl-8S,16S-bis(oxazol-5-ylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione. Molecular Formula: C27H36N2O6. Formula Weight: 484.6. Purity: >95%. Formulation: (Request formulation change), A solid. SMILES: C/C(C(O[C@@H](CC1=CN=CO1)[C@@H](C)C[C@@H](C)/C=C2\C)=O)=C\CC[C@H](C)[C@H](CC3=CN=CO3)OC2=O. InChi Code: InChI=1S/C27H36N2O6/c1-17-9-20(4)25(12-23-14-29-16-33-23)35-26(30)19(3)8-6-7-18(2)24(11-22-13-28-15-32-22)34-27(31)21(5)10-17/h8,10,13-18,20,24-25H,6-7,9,11-12H2,1-5H3/b19-8+,21-10+/t17-,18+,20+,24+,25+/m1/s1. InChi Key: ZSFACGJIQJJPDW-MWWGJRGRSA-N. Origin: Bacterium/Streptomyces conglobatus.