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Description: CMP8 is a selective ligand for estrogen receptor. CMP8 binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 has IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERalpha, MGRERalpha, hERalpha and hERbeta, respectively. Target: Estrogen/progestogen Receptor, Estrogen Receptor/ERR. Smiles: C(C12C(C=3C(C1)=CC(O)=CC3)=C(C(=O)CC2)C4=CC=C(OCCN5CCCCC5)C=C4)C6=CC=C(Cl)C=C6. References: Miyazaki Y, et al. Destabilizing domains derived from the human estrogen receptor. J Am Chem Soc. 2012 Mar 7,134(9):3942-5.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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