CLOZAPINE N-OXIDE
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier... more
Product information "CLOZAPINE N-OXIDE"
Description: Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist. Target: AChR, Drug Metabolite, 5-HT Receptor, Dopamine Receptor. Smiles: CN1(=O)CCN(C=2C=3C(NC=4C(N2)=CC(Cl)=CC4)=CC=CC3)CC1. References: Jendryka M, et al. Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice. Sci Rep. 2019 Mar 14,9(1):4522.
| Supplier: | TargetMol |
| Supplier-Nr: | T4494 |
Properties
| Application: | 5-HT2 serotonin receptor antagonist |
| MW: | 342.82 D |
| Formula: | C18H19ClN4O |
Database Information
| CAS : | 34233-69-7| Matching products |
| KEGG ID : | K04157 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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