Clothianidin

Clothianidin is a neonicotinoid insecticide and an active metabolite of the prodrug thiamethoxam (Cay-25784). It binds to nicotinic acetylcholine receptors (nAChRs, IC50 = 0.6 nM for housefly head membranes) and activates non-desensitizing nAChRs in cockroach neurons in vitro (IC50 = 1,520 nM). Clothianidin induces mortality in adult M. persicae (LC95 = 1.28 mg/L), as well as H. virescens and S. frugiperda second instar larvae when used at a concentration of 8 mg/L in a leaf-dip bioassay. In vivo, clothianidin (>25 mg/kg) increases the number of premature births in rabbits and reduces the length and weight of fathead minnows (P. promelas) when administered in tank water at a concentration of 20 mg/L. Formulations containing clothianidin have been used as insecticides in residential and agricultural settings.Formal Name: [C(E)]-N-[(2-chloro-5-thiazolyl)methyl]-N'-methyl-N''-nitro-guanidine. CAS Number: 210880-92-5. Molecular Formula: C6H8ClN5O2S. Formula Weight: 249.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml. lambdamax: 220, 269 nm. SMILES: ClC1=NC=C(CN/C(NC)=N/[N+]([O-])=O)S1. InChi Code: InChI=1S/C6H8ClN5O2S/c1-8-6(11-12(13)14)10-3-4-2-9-5(7)15-4/h2H,3H2,1H3,(H2,8,10,11). InChi Key: PGOOBECODWQEAB-UHFFFAOYSA-N.