Clonidine-d4 (hydrochloride)

Clonidine-d4 (hydrochloride)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay28519-2.5 2500 µg -

6 - 10 business days*

746.00€
 
Clonidine-d4 is intended for use as an internal standard for the quantification of clonidine... more
Product information "Clonidine-d4 (hydrochloride)"
Clonidine-d4 is intended for use as an internal standard for the quantification of clonidine (Cay-15949) by GC- or LC-MS. Clonidine is an agonist of alpha2-adrenergic receptors (alpha2-ARs, Kis = 61.66, 69.18, and 134.9 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively). It stimulates [35S]GTPgammaS binding to HEK293 cell membranes expressing the human receptors with EC50 values of 26.92, 56.23, and 912.01 nM for alpha2A-, alpha2B-, and alpha2C-ARs, respectively. Clonidine also binds to I1-imidazoline sites in a variety of cell and tissue types (Kds = 4-15 nM). It induces relaxation of isolated mesenteric artery rings precontracted with norepinephrine (Cay-16673) when used at a concentration of 10 µM. Clonidine (10 µM) also induces membrane hyperpolarization and reduces norepinephrine-induced depolarization in isolated mesenteric artery rings. Clonidine (0.1 and 1 µg/kg) reduces mean blood pressure and heart rate when administered via microinjection to the nucleus reticularis lateralis (NRL) of anesthetized normotensive cats. Formulations containing clonidine have been used in the treatment of hypertension.Formal Name: N-(2,6-dichlorophenyl)-4,5-dihydro-d2-1H-imidazol-4,5-d2-2-amine, monohydrochloride. CAS Number: 67151-02-4. Molecular Formula: C9H5Cl2D4N3 . HCl. Formula Weight: 270.6. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: ClC1=C(NC2=NC([2H])([2H])C([2H])([2H])N2)C(Cl)=CC=C1.Cl. InChi Code: InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9,/h1-3H,4-5H2,(H2,12,13,14),1H/i4D2,5D2,. InChi Key: ZNIFSRGNXRYGHF-HGFPCDIYSA-N.
Keywords: N-(2,6-dichlorophenyl)-4,5-dihydro-d2-1H-imidazol-4,5-d2-2-amine, monohydrochloride
Supplier: Cayman Chemical
Supplier-Nr: 28519

Properties

Application: GC-MS, LC-MS, Internal standard, Quantification, Alpha2-adrenergic receptor agonist
MW: 270.6 D
Formula: C9H5Cl2D4N3 . HCl
Purity: >99% deuterated forms (d1-d4)
Format: Solid

Database Information

CAS : 67151-02-4| Matching products
KEGG ID : K04138 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H301, H330
P Phrases: P260, P264, P270, P271, P284, P301+310, P304+340, P310, P320, P321, P330, P403+233, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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