Clobetasol Propionate-d5

Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate (Cay-21251) by GC- or LC-MS. Clobetasol propionate is a corticosteroid. It binds to glucocorticoid receptors in a cell-free assay (IC50 = 3.17 nM) and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml. Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice. Formulations containing clobetasol propionate have been used in the treatment of inflammatory skin conditions.Formal Name: 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy-2,2,3,3,3-d5)-(11beta,16beta)-pregna-1,4-diene-3,20-dione. CAS Number: 2280940-18-1. Synonyms: CCI-4725-d5, CGP 9555-d5, Clobetasol 17-propionate-d5. Molecular Formula: C25H27ClD5FO5. Formula Weight: 472.0. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: Methanol: soluble. SMILES: O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@@]4(C(CCl)=O)OC(C([2H])([2H])C([2H])([2H])[2H])=O)=C1. InChi Code: InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1/i1D3,5D2. InChi Key: CBGUOGMQLZIXBE-BFHSNLKKSA-N.