CKI-7 (hydrochloride)

CKI-7 is an inhibitor of casein kinase 1 (CK1, Ki = 8.5 µM). It is selective for CK1 over CK2, PKC, CaM kinase II (CaMKII), and cyclic AMP-dependent protein kinase (IC50s = 90, >1,000, 195, and 550 µM, respectively). CKI-7 inhibits phosphorylation of a peptide substrate by Leishmania CK1.2 by 50% when used at a concentration of 10 µM.Formal Name: N-(2-aminoethyl)-5-chloro-8-isoquinolinesulfonamide, dihydrochloride. CAS Number: 1177141-67-1. Molecular Formula: C11H12ClN3O2S . 2HCl. Formula Weight: 358.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Slightly soluble, Water: Sparingly soluble (heated). SMILES: ClC1=C(C=CN=C2)C2=C(S(NCCN)(=O)=O)C=C1.Cl.Cl. InChi Code: InChI=1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10,,/h1-3,5,7,15H,4,6,13H2,2*1H. InChi Key: JUAVTXYOCISSSL-UHFFFAOYSA-N.