CK-666

CK-666 is an inhibitor of the actin-related protein 2/3 (Arp2/3) complex (IC50s = 4, 17, and 5 µM for the human, bovine, and S. pombe complexes, respectively, in an actin polymerization assay). It binds at the Arp2/3 interface, stabilizing the inactive conformation of the complex. CK-666 (40 µM) inhibits actin comet tail formation around intracellular L. monocytogenes in infected SKOV3 cells. It induces actin remodeling, inhibits lamellipodia formation, and reduces the motility rate in M-1 epithelial cells when used at a concentration of 200 µM. CK-666 (100 µM) impairs long-term fear memory formation in rats when microinjected into the lateral amygdala.Formal Name: 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-benzamide. CAS Number: 442633-00-3. Molecular Formula: C18H17FN2O. Formula Weight: 296.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 226, 273 nm. SMILES: CC1=C(CCNC(C2=CC=CC=C2F)=O)C3=CC=CC=C3N1. InChi Code: InChI=1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22). InChi Key: UXRKUKRXVWJFER-UHFFFAOYSA-N.