Citalopram (hydrobromide)

Citalopram is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with an IC50 value of 1.8 nM for 5-HT reuptake in rat brain synaptosomes. It is selective for 5-HT reuptake over that of dopamine and norepinephrine (IC50s = >6 mM). Citalopram potentiates headweaving and tremor induced by 5-hydroxy-L-tryptophan (Cay-20539) in mice (ED50s = 0.61 and 0.66 mmol/kg, respectively). It also acts as an antagonist of nicotinic acetylcholine receptors (IC50 = 0.93 µM). Formulations containing citalopram have been used to treat depression. This product is also available as an analytical reference standard (Cay-23252).Formal Name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, monohydrobromide. CAS Number: 59729-32-7. Synonyms: Bonitrile, Lu 10-171B, Nitalapram, Prepram. Molecular Formula: C20H21FN2O . HBr. Formula Weight: 405.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 204, 238 nm. SMILES: CN(C)CCCC1(C2=CC=C(F)C=C2)OCC3=CC(C#N)=CC=C31. InChi Code: InChI=1S/C20H21FN2O/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20/h4-9,12H,3,10-11,14H2,1-2H3. InChi Key: WSEQXVZVJXJVFP-UHFFFAOYSA-N.