Cisplatin

Cisplatin is a platinum-containing compound that acts as a DNA-crosslinking agent and interferes with replication and transcription, culminating in apoptosis. It forms intra- and interstrand crosslinks with DNA with intrastrand guanine-to-guanine or guanine-to-alanine links accounting for the majority of DNA binding. Cisplatin halts the cell cycle at the G2/M phase in vitro and is active against murine tumors transplanted into mice and in mouse xenograft models, including a reduction in tumor growth in a model of squamous cell carcinoma of the head and neck when administered at doses ranging from 7.5 to 12.5 mg/kg. Cisplatin also inhibits the RecA recombinase of M. tuberculosis (IC50 = 2 µM), blocking protein splicing and cell growth. Formulations containing cisplatin have been used, alone and in combination therapy, in the treatment of a variety of cancers.Formal Name: (SP-4-2)-diamminedichloro-platinum. CAS Number: 15663-27-1. Synonyms: CDDP, cis-Diamminedichloroplatinum, Cisplatinum, NSC 119875. Molecular Formula: Cl2H6N2Pt. Formula Weight: 300.1. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 20 mg/ml**, PBS (pH 7.2): 1 mg/ml (with warming), Water: 1 mg/ml (with warming). SMILES: [Cl-][Pt+2]([NH3])([NH3])[Cl-]. InChi Code: InChI=1S/2ClH.2H3N.Pt/h2*1H,2*1H3,/q,,,,+2/p-2. InChi Key: LXZZYRPGZAFOLE-UHFFFAOYSA-L.