Cinnarizine

Cinnarizine is a calcium channel inhibitor and histamine H4 receptor antagonist (Ki = 142 nM). It inhibits L- and T-type calcium channels in isolated guinea pig atrial cells in a voltage-dependent manner. Cinnarizine inhibits L-type calcium currents in isolated guinea pig type II vestibular hair cells (IC50 = 1.5 µM). In vivo, cinnarizine (10 mg/kg) inhibits ethanol-induced gastric ulcer formation in rats. Formulations containing cinnarizine have been used in the treatment of nausea and vomiting due to vertigo, Meniere's disease, or chemotherapy.Formal Name: 1-(diphenylmethyl)-4-(3-phenyl-2-propen-1-yl)-piperazine. CAS Number: 298-57-7. Molecular Formula: C26H28N2. Formula Weight: 368.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 14 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/mol, DMSO: 2 mg/ml, Ethanol: 3 mg/ml. lambdamax: 227, 251 nm. SMILES: C1(C(C2=CC=CC=C2)N3CCN(C/C=C/C4=CC=CC=C4)CC3)=CC=CC=C1. InChi Code: InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+. InChi Key: DERZBLKQOCDDDZ-JLHYYAGUSA-N.