Cilnidipine-d7

Cilnidipine-d7 is intended for use as an internal standard for the quantification of cilnidipine (Cay-26080) by GC- or LC-MS. Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 µM. Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats. It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 µg/kg. Cilnidipine (100 µg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.Formal Name: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(2-methoxyethyl-d7) 5-[(2E)-3-phenyl-2-propen-1-yl] ester. Molecular Formula: C27H21D7N2O7. Formula Weight: 499.6. Purity: >99% deuterated forms (d1-d7). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: O=C(C1=C(C)NC(C)=C(C(OC([2H])([2H])C([2H])([2H])OC([2H])([2H])[2H])=O)C1C2=CC([N+]([O-])=O)=CC=C2)OC/C=C/C3=CC=CC=C3. InChi Code: InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+/i3D3,15D2,16D2. InChi Key: KJEBULYHNRNJTE-UPZNXPSBSA-N.