Chrysosplenetin

Chrysosplenetin is a flavonoid that has been found in A. annua and has diverse biological activities. It is active against P. falciparum in vitro (IC50 = 23 µM). Chrysosplenetin inhibits the cytopathic effect of enterovirus 71 (EV71) in Vero cells (EC50 = 0.68 µM) and increases survival in a neonatal mouse model of EV71 infection when administered at doses of 1 and 5 mg/kg. It also increases proliferation and osteogenic differentiation of isolated human bone marrow stromal cells (BMSCs) and prevents estrogen deficiency-induced bone loss in ovariectomized mice.Formal Name: 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-1-benzopyran-4-one. CAS Number: 603-56-5. Synonyms: Chrysosplenol B, Chrysosptertin B, EMD 20940, Polycladin. Molecular Formula: C19H18O8. Formula Weight: 374.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Methanol: soluble. lambdamax: 257, 271, 350 nm. SMILES: COC1=C(OC)C=C(OC(C2=CC=C(O)C(OC)=C2)=C(OC)C3=O)C3=C1O. InChi Code: InChI=1S/C19H18O8/c1-23-11-7-9(5-6-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3. InChi Key: NBVTYGIYKCPHQN-UHFFFAOYSA-N. Origin: Plant/Laggera pterodonta.