Chrodrimanin B

Chrodrimanin B is a meroterpenoid fungal metabolite that has been found in Talaromyces species. It has insecticidal activity against third instar silkworm larvae (LD50 = 10 µg/g of diet). Chrodrimanin B selectively inhibits the silkworm GABA receptor RDL (IC50 = 1.13 nM) over human alpha1beta2gamma2 subunit-containing GABA receptors (IC50 = 1.48 µM). The structure of thailandolide B, originally described as a C-9 epimer of chrodrimanin B, was revised in 2012 and is identical to that of chrodrimanin B.Formal Name: (1R,2R,7aR,8S,9aR,13aS,13bS)-1-(acetyloxy)-1,8,9,9a,10,13a,13b,14-octahydro-5,8-dihydroxy-2,7a,10,10,13a-pentamethyl-2H,4H-benzo[a]pyrano[3,4-j]xanthene-4,11(7aH)-dione. CAS Number: 132196-54-4. Synonyms: Thailandolide B. Molecular Formula: C27H32O8. Formula Weight: 484.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: 1 mg/ml, Methanol: Soluble. SMILES: O=C(C)O[C@H]1[C@@H](C)OC(C2=C1C3=C(C=C2O)O[C@@]([C@@]4([H])C3)(C)[C@@H](O)C[C@@]([C@]4(C)C=C5)([H])C(C)(C)C5=O)=O. InChi Code: InChI=1S/C27H32O8/c1-12-23(34-13(2)28)21-14-9-18-26(5)8-7-19(30)25(3,4)17(26)11-20(31)27(18,6)35-16(14)10-15(29)22(21)24(32)33-12/h7-8,10,12,17-18,20,23,29,31H,9,11H2,1-6H3/t12-,17+,18+,20+,23+,26+,27-/m1/s1. InChi Key: DYQKBALSPZQWQD-FWEFFTEASA-N. Origin: Fungus/Penicillium sp..