CHM-081

Description: JWH 081, a cannabimimetic aminoalkylindole, has a high-affinity to the central cannabinoid (CB1) receptor (Ki =1.2 nM) and ten-fold reduced affinity to the peripheral cannabinoid (CB2) receptor (Ki = 12.4 nM). JWH 081-N-(cyclohexylmethyl) analog is a synthetic CB where a cyclohexylmethyl group replaces the alkyl group of the parent compound. Its physiological and toxicological properties have not been evaluated. Target: Others. Smiles: C(=O)(C=1C=2C(N(CC3CCCCC3)C1)=CC=CC2)C=4C5=C(C(OC)=CC4)C=CC=C5. References: Blakey K, Boyd S, Atkinson S, Wolf J, Slottje PM, Goodchild K, McGowan J. Identification of the novel synthetic cannabimimetic 8-quinolinyl 4-methyl-3-(1-piperidinylsulfonyl)benzoate (QMPSB) and other designer drugs in herbal incense. Forensic Sci Int. 2016 Mar,260:40-53. doi: 10.1016/j.forsciint.2015.12.001. Epub 2015 Dec 14. PubMed PMID: 26795397.