Chlorpheniramine (maleate)

Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 µg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.Formal Name: gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine, 2Z-butenedioate. CAS Number: 113-92-8. Synonyms: (±)-Chlorpheniramine, Chlorprophenpyridamine. Molecular Formula: C16H19ClN2 . C4H4O4. Formula Weight: 390.9. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 262 nm. SMILES: ClC(C=C1)=CC=C1C(CCN(C)C)C2=CC=CC=N2.OC(/C=C\C(O)=O)=O. InChi Code: InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13,5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3,1-2H,(H,5,6)(H,7,8)/b,2-1-. InChi Key: DBAKFASWICGISY-BTJKTKAUSA-N.