Chlorothiazide

Chlorothiazide is a first-in-class thiazide diuretic initially discovered from its ability to inhibit carbonic anhydrase in vitro. As an antihypertensive agent, this thiazide increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.Formal Name: 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide. CAS Number: 58-94-6. Synonyms: Diuril, NSC 25693. Molecular Formula: C7H6ClN3O4S2. Formula Weight: 295.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml. lambdamax: 226, 279 nm. SMILES: O=S1(C2=CC(S(N)(=O)=O)=C(Cl)C=C2N=CN1)=O. InChi Code: InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13). InChi Key: JBMKAUGHUNFTOL-UHFFFAOYSA-N.