Chlorhexidine (acetate hydrate)

Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent. It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 µg/ml). It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP, MIC90s = 4, 2, 2, and 1 mg/L, respectively). Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 µg/ml) and C. albicans (MIC = 5.15 µg/ml). It generates cations that bind to and destabilize the bacterial cell wall to induce death. Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay. Formulations containing chlorhexidine have been used in antiseptic wound dressings, mouthwash, and toothpaste.Formal Name: N,N''-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide, diacetate, hydrate. CAS Number: 206986-79-0. Synonyms: CHX. Molecular Formula: C22H30Cl2N10 . 2C2H4O2 [XH2O]. Formula Weight: 625.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/mL, DMSO: 15 mg/mL, DMSO:PBS(pH 7.2) (1:2): 0.33 mg/mL, Ethanol: 10 mg/mL. lambdamax: 261 nm. SMILES: ClC1=CC=C(NC(NC(NCCCCCCNC(NC(NC2=CC=C(Cl)C=C2)=N)=N)=N)=N)C=C1.CC(O)=O.CC(O)=O.O. InChi Code: InChI=1S/C22H30Cl2N10.2C2H4O2.H2O/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18,2*1-2(3)4,/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34),2*1H3,(H,3,4),1H2. InChi Key: JGFZDLOXFRFUTG-UHFFFAOYSA-N.